Thymidylate Synthase as a Predictive Biomarker for Pemetrexed Response in NSCLC
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چکیده
منابع مشابه
Thymidylate Synthase as a Predictive Biomarker for Pemetrexed Response in NSCLC
In recent years, major strides in cancer research have made it possible to select personalized chemotherapy recommendations based on an individual patient's tumor biology. The prognostic and/or predictive ability of biomarkers seeks to tailor the use of targeted chemotherapy and can result in improved clinical outcomes with reduced toxicity. A proliferation of new technology and pharmacotherape...
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BACKGROUND Although it has been suggested that a high level of thymidylate synthase (TYMS) gene expression in malignant tumors is related to reduced sensitivity to the antifolate drug pemetrexed, no direct evidence for such an association has been demonstrated in routine clinical samples from patients treated with the drug. The purpose of this study was to quantitatively assess the impact of TY...
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Significant advances have been made in the treatment of advanced colorectal cancer. At present, there are four main active drugs to treat the disease, and they include the fluoropyrimidines, 5-fluorouracil (5-FU) and capecitabine, irinotecan, and oxaliplatin. Over the past few years, intense research efforts have focused on developing molecular biomarkers that could predict response to these va...
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Combination of platinum compounds/pemetrexed has become the standard first-line treatment of malignant pleural mesothelioma (MPM) [1], but predictors of responsiveness to pemetrexed and/or cisplatin/carboplatin are still lacking. Recently, Righi et al. [2] retrospectively investigated the correlation between expression of thymidylate synthase (TS) and excision repair cross-complementation group...
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Pemetrexed (PEM), a multi-targeted antifolate, has promising clinical activity in non-squamous non-small cell lung cancer. However, the majority of patients eventually acquire resistance to PEM. To evaluate the resistant mechanisms, the A549 lung adenocarcinoma cell line was exposed to stepwise increasing PEM concentrations of 1.6, 6.4 and 16 μM to establish three PEM-resistant lung cancer cell...
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ژورنال
عنوان ژورنال: Lung Cancer International
سال: 2013
ISSN: 2090-3197,2090-3200
DOI: 10.1155/2013/436409